O evento teve lugar em Inglewood, Califórnia, e destacou uma vez mais a cantora Taylor Swift pelo seu álbum '1989'. A noite ficou também marcada por Calvin Harris que recebeu o agradecimento mais emotivo da sua carreira.
LISTA DE VENCEDORES:
- Song of the Year: "Hello" – Adele
- Female Artist of the Year: Taylor Swift
- Male Artist of the Year: Justin Bieber
- Best New Artist: Fetty Wap
- Best Duo/Group of the Year: Maroon 5
- Album of the Year: 1989 – Taylor Swift
- Best Tour: Taylor Swift
- Alternative Rock Artist of the Year: Twenty One Pilots
- Alternative Rock Song of the Year: "Stressed Out" – Twenty One Pilots
- Rock Artist of the Year: Foo Fighters
- Rock Song of the Year: "Heavy Is the Head" – Zac Brown Band featuring Chris Cornell
- Country Song of the Year: "Buy Me a Boat" – Chris Janson
- Country Artist of the Year: Luke Bryan
- Dance Song of the Year: "Where Are Ü Now" – Skrillex & Diplo with Justin Bieber
- Dance Artist of the Year: Calvin Harris
- Hip Hop Song of the Year: "Hotline Bling" – Drake
- Hip Hop Artist of the Year: Drake
- R&B Song of the Year: "Earned It" – The Weeknd
- R&B Artist of the Year: Chris Brown
- Latin Song of the Year: "El Perdón" – Nicky Jam & Enrique Iglesias
- Latin Artist of the Year: Pitbull
- Regional Mexican Song of the Year: "Levantando Polvadera" – Voz de Mando
- Regional Mexican Artist of the Year: Banda Los Recoditos
- Best Lyrics:"Fight Song" – Rachel Platten
- Best Collaboration: "Uptown Funk" – Mark Ronson featuring Bruno Mars
- Best Cover Song: "Uptown Funk" – Fifth Harmony, Jasmine V, Jacob Whitesides and Mahogany Lox covering Mark Ronson featuring Bruno Mars
- Best Song from a Movie: "Til It Happens To You" – Lady Gaga (The Hunting Ground)
- Most Meme-able Moment: Taylor Swift’s "Crazy Girl" with Running Mascara (from "Blank Space" video)
- Triple Threat - Selena Gomez – Singer/Actor/Dancer
- Best Fan Army: Justin Bieber – Beliebers